Optical Tomography with Ultrasound Localization for Breast Cancer Diagnosis and Treatment Monitoring
Optical tomography with ultrasound (US) localization uses coregistered ultrasound images to guide optical imaging reconstruction. To simultaneously acquire US images and optical measurements, the authors used a hand-held probe consisting of a commercial US transducer and near-infrared optical imaging sensors of multiple wavelengths. A novel image scheme was used to map the ultrasound-visible lesions for optical imaging reconstruction. As a result, the problem of intense light scattering caused by breast tissue was overcome and reliable tumor hemoglobin concentration and blood oxygen saturation distributions from a group of patients were obtained. These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response.
aBioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA
bCancer Center, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
cWaterbury Hospital Health Center, 64 Robbins Street, Waterbury, CT 06721, USA
Corresponding author. Waterbury Hospital Health Center, 64 Robbins Street, Waterbury, CT 06721.
The following funding agents are thanked for their funding support: the National Institutes of Health (R01EB002136), the Donaghue Foundation, the ARMY Medical Research and Materiel Command (DAMD17-00-1-0217), and the State of Connecticut.
ABSTRACT