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Management of Synchronous Colorectal Cancer Metastases

Published:March 09, 2022DOI:https://doi.org/10.1016/j.soc.2021.11.007

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      References

        • Hu C.Y.
        • Bailey C.E.
        • You Y.N.
        • et al.
        Time trend analysis of primary tumor resection for stage IV colorectal cancer: less surgery, improved survival.
        JAMA Surg. 2015; 150: 245-251
        • Brouwer N.P.M.
        • Bos A.
        • Lemmens V.
        • et al.
        An overview of 25 years of incidence, treatment and outcome of colorectal cancer patients.
        Int J Cancer. 2018; 143: 2758-2766
        • Siegel R.L.
        • Miller K.D.
        • Jemal A.
        Cancer statistics, 2019.
        CA Cancer J Clin. 2019; 69: 7-34
        • Ansa B.E.
        • Coughlin S.S.
        • Alema-Mensah E.
        • et al.
        Evaluation of colorectal cancer incidence trends in the United States (2000-2014).
        J Clin Med. 2018; 7: 22
        • Wang J.
        • Li S.
        • Liu Y.
        • et al.
        Metastatic patterns and survival outcomes in patients with stage IV colon cancer: a population-based analysis.
        Cancer Med. 2020; 9: 361-373
        • Vogel J.D.
        • Eskicioglu C.
        • Weiser M.R.
        • et al.
        The American Society of Colon and rectal surgeons clinical practice guidelines for the treatment of colon cancer.
        Dis Colon Rectum. 2017; 60: 999-1017
        • Benson 3rd, A.B.
        • Venook A.P.
        • Cederquist L.
        • et al.
        Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology.
        J Natl Compr Canc Netw. 2017; 15: 370-398
        • Adams R.B.
        • Aloia T.A.
        • Loyer E.
        • et al.
        Selection for hepatic resection of colorectal liver metastases: expert consensus statement.
        HPB (Oxford). 2013; 15: 91-103
        • Abdalla E.K.
        • Bauer T.W.
        • Chun Y.S.
        • et al.
        Locoregional surgical and interventional therapies for advanced colorectal cancer liver metastases: expert consensus statements.
        HPB (Oxford). 2013; 15: 119-130
        • Schwarz R.E.
        • Berlin J.D.
        • Lenz H.J.
        • et al.
        Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement.
        HPB (Oxford). 2013; 15: 106-115
        • Morris A.M.
        Shared decision making for rectal cancer care: a long way forward.
        Dis Colon Rectum. 2016; 59: 905-906
        • Hawley S.T.
        • Jagsi R.
        Shared decision making in cancer care: does one size fit all?.
        JAMA Oncol. 2015; 1: 58-59
        • Ellis P.G.
        • O'Neil B.H.
        • Earle M.F.
        • et al.
        Clinical pathways: management of quality and cost in oncology networks in the metastatic colorectal cancer setting.
        J Oncol Pract. 2017; 13: e522-e529
        • Deans G.T.
        • Krukowski Z.H.
        • Irwin S.T.
        Malignant obstruction of the left colon.
        Br J Surg. 1994; 81: 1270-1276
        • van Hooft J.E.
        • van Halsema E.E.
        • Vanbiervliet G.
        • et al.
        Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) clinical guideline.
        Endoscopy. 2014; 46: 990-1053
        • Fiori E.
        • Lamazza A.
        • Schillaci A.
        • et al.
        Palliative management for patients with subacute obstruction and stage IV unresectable rectosigmoid cancer: colostomy versus endoscopic stenting: final results of a prospective randomized trial.
        Am J Surg. 2012; 204: 321-326
        • Gianotti L.
        • Tamini N.
        • Nespoli L.
        • et al.
        A prospective evaluation of short-term and long-term results from colonic stenting for palliation or as a bridge to elective operation versus immediate surgery for large-bowel obstruction.
        Surg Endosc. 2013; 27: 832-842
        • Young C.J.
        • De-Loyde K.J.
        • Young J.M.
        • et al.
        Improving quality of life for people with incurable large-bowel obstruction: randomized control trial of colonic stent insertion.
        Dis Colon Rectum. 2015; 58: 838-849
        • van den Berg M.W.
        • Ledeboer M.
        • Dijkgraaf M.G.
        • et al.
        Long-term results of palliative stent placement for acute malignant colonic obstruction.
        Surg Endosc. 2015; 29: 1580-1585
        • Watt A.M.
        • Faragher I.G.
        • Griffin T.T.
        • et al.
        Self-expanding metallic stents for relieving malignant colorectal obstruction: a systematic review.
        Ann Surg. 2007; 246: 24-30
        • Gao P.
        • Huang X.Z.
        • Song Y.X.
        • et al.
        Impact of timing of adjuvant chemotherapy on survival in stage III colon cancer: a population-based study.
        BMC Cancer. 2018; 18: 234
        • Cameron M.G.
        • Kersten C.
        • Vistad I.
        • et al.
        Palliative pelvic radiotherapy of symptomatic incurable rectal cancer - a systematic review.
        Acta Oncol. 2014; 53: 164-173
        • Cameron M.G.
        • Kersten C.
        • Vistad I.
        • et al.
        Palliative pelvic radiotherapy for symptomatic rectal cancer - a prospective multicenter study.
        Acta Oncol. 2016; 55: 1400-1407
        • Corvino F.
        • Giurazza F.
        • Cangiano G.
        • et al.
        Endovascular treatment of peripheral vascular blowout syndrome in end-stage malignancies.
        Ann Vasc Surg. 2019; 58: 382.e1-382.e5
        • Tan K.K.
        • Strong D.H.
        • Shore T.
        • et al.
        The safety and efficacy of mesenteric embolization in the management of acute lower gastrointestinal hemorrhage.
        Ann Coloproctol. 2013; 29: 205-208
        • Daniels M.
        • Merkel S.
        • Agaimy A.
        • et al.
        Treatment of perforated colon carcinomas-outcomes of radical surgery.
        Int J Colorectal Dis. 2015; 30: 1505-1513
        • Lam V.W.
        • Laurence J.M.
        • Pang T.
        • et al.
        A systematic review of a liver-first approach in patients with colorectal cancer and synchronous colorectal liver metastases.
        HPB (Oxford). 2014; 16: 101-108
        • Poultsides G.A.
        • Servais E.L.
        • Saltz L.B.
        • et al.
        Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment.
        J Clin Oncol. 2009; 27: 3379-3384
        • Kopetz S.
        • Grothey A.
        • Yaeger R.
        • et al.
        Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer.
        N Engl J Med. 2019; 381: 1632-1643
        • Adam R.
        • De Gramont A.
        • Figueras J.
        • et al.
        The oncosurgery approach to managing liver metastases from colorectal cancer: a multidisciplinary international consensus.
        Oncologist. 2012; 17: 1225-1239
        • Bolhuis K.
        • Grosheide L.
        • Wesdorp N.J.
        • et al.
        • for the Dutch Colorectal Cancer Group Liver Expert Panel
        Short-term outcomes of secondary liver surgery for initially unresectable colorectal liver metastases following modern induction systemic therapy in the dutch CAIRO5 trial.
        Ann Surg Open. 2021; 2: e081
        • Faron M.
        • Pignon J.P.
        • Malka D.
        • et al.
        Is primary tumour resection associated with survival improvement in patients with colorectal cancer and unresectable synchronous metastases? A pooled analysis of individual data from four randomised trials.
        Eur J Cancer. 2015; 51: 166-176
        • Shida D.
        • Boku N.
        • Tanabe T.
        • et al.
        Primary tumor resection for stage IV colorectal cancer in the era of targeted chemotherapy.
        J Gastrointest Surg. 2019; 23: 2144-2150
        • Kanemitsu Y.
        • Shitara K.
        • Mizusawa J.
        • et al.
        Primary tumor resection plus chemotherapy versus chemotherapy alone for colorectal cancer patients with asymptomatic, synchronous unresectable metastases (JCOG1007; iPACS): a randomized clinical trial.
        J Clin Oncol. 2021; 39: 1098-1107
        • Moritani K.
        • Kanemitsu Y.
        • Shida D.
        • et al.
        A randomized controlled trial comparing primary tumour resection plus chemotherapy with chemotherapy alone in incurable stage IV colorectal cancer: JCOG1007 (iPACS study).
        Jpn J Clin Oncol. 2020; 50: 89-93
        • Cotte E.
        • Villeneuve L.
        • Passot G.
        • et al.
        GRECCAR 8: impact on survival of the primary tumor resection in rectal cancer with unresectable synchronous metastasis: a randomized multicentre study.
        BMC Cancer. 2015; 15: 47
        • Lam-Boer J.
        • Mol L.
        • Verhoef C.
        • et al.
        The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer--a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG).
        BMC Cancer. 2014; 14: 741
        • Creasy J.M.
        • Sadot E.
        • Koerkamp B.G.
        • et al.
        Actual 10-year survival after hepatic resection of colorectal liver metastases: what factors preclude cure?.
        Surgery. 2018; 163: 1238-1244
        • Fernandez F.G.
        • Ritter J.
        • Goodwin J.W.
        • et al.
        Effect of steatohepatitis associated with irinotecan or oxaliplatin pretreatment on resectability of hepatic colorectal metastases.
        J Am Coll Surg. 2005; 200: 845-853
        • Simpson A.L.
        • Leal J.N.
        • Pugalenthi A.
        • et al.
        Chemotherapy-induced splenic volume increase is independently associated with major complications after hepatic resection for metastatic colorectal cancer.
        J Am Coll Surg. 2015; 220: 271-280
        • Khan A.Z.
        • Morris-Stiff G.
        • Makuuchi M.
        Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases.
        J Hepatobiliary Pancreat Surg. 2009; 16: 137-144
        • Duwe G.
        • Knitter S.
        • Pesthy S.
        • et al.
        Hepatotoxicity following systemic therapy for colorectal liver metastases and the impact of chemotherapy-associated liver injury on outcomes after curative liver resection.
        Eur J Surg Oncol. 2017; 43: 1668-1681
        • Jamnagerwalla M.
        • Tay R.
        • Steel M.
        • et al.
        Impact of surgical complications following resection of locally advanced rectal adenocarcinoma on adjuvant chemotherapy delivery and survival outcomes.
        Dis Colon Rectum. 2016; 59: 916-924
        • Habr-Gama A.
        • Sao Juliao G.P.
        • Fernandez L.M.
        • et al.
        Achieving a complete clinical response after neoadjuvant chemoradiation that does not require surgical resection: it may take longer than you think!.
        Dis Colon Rectum. 2019; 62: 802-808
        • Dattani M.
        • Heald R.J.
        • Goussous G.
        • et al.
        Oncological and survival outcomes in watch and wait patients with a clinical complete response after neoadjuvant chemoradiotherapy for rectal cancer: a systematic review and pooled analysis.
        Ann Surg. 2018; 268: 955-967
        • Renehan A.G.
        • Malcomson L.
        • Emsley R.
        • et al.
        Watch-and-wait approach versus surgical resection after chemoradiotherapy for patients with rectal cancer (the OnCoRe project): a propensity-score matched cohort analysis.
        Lancet Oncol. 2016; 17: 174-183
        • Smith J.J.
        • Strombom P.
        • Chow O.S.
        • et al.
        Assessment of a watch-and-wait strategy for rectal cancer in patients with a complete response after neoadjuvant therapy.
        JAMA Oncol. 2019; 5: e185896
        • Ferrarotto R.
        • Pathak P.
        • Maru D.
        • et al.
        Durable complete responses in metastatic colorectal cancer treated with chemotherapy alone.
        Clin Colorectal Cancer. 2011; 10: 178-182
        • Zaydfudim V.M.
        • McMurry T.L.
        • Harrigan A.M.
        • et al.
        Improving treatment and survival: a population-based study of current outcomes after a hepatic resection in patients with metastatic colorectal cancer.
        HPB (Oxford). 2015; 17: 1019-1024
        • Venook A.C.
        Management of potentially resectable colorectal liver metastases.
        UpToDate, 2020 (Available at:) (Accessed 2020)
        • Kambakamba P.
        • Hoti E.
        • Cremen S.
        • et al.
        The evolution of surgery for colorectal liver metastases: a persistent challenge to improve survival.
        Surgery. 2021 Dec; 170: 1732-1740
        • Takamoto T.
        • Sano K.
        • Hashimoto T.
        • et al.
        Practical contribution of virtual hepatectomy for colorectal liver metastases: a propensity-matched analysis of clinical outcome.
        J Gastrointest Surg. 2018; 22: 2037-2044
        • Ethun C.G.
        • Maithel S.K.
        Determination of resectability.
        Surg Clin North Am. 2016; 96: 163-181
        • Shindoh J.
        • Truty M.J.
        • Aloia T.A.
        • et al.
        Kinetic growth rate after portal vein embolization predicts posthepatectomy outcomes: toward zero liver-related mortality in patients with colorectal liver metastases and small future liver remnant.
        J Am Coll Surg. 2013; 216: 201-209
        • Laurent C.
        • Fernandez B.
        • Marichez A.
        • et al.
        Radiological simultaneous portohepatic vein embolization (RASPE) before major hepatectomy: a better way to optimize liver hypertrophy compared to portal vein embolization.
        Ann Surg. 2020; 272: 199-205
        • Shindoh J.
        • Vauthey J.N.
        • Zimmitti G.
        • et al.
        Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach.
        J Am Coll Surg. 2013; 217 ([discussion 124–33]): 126-133
        • Capussotti L.
        • Muratore A.
        • Baracchi F.
        • et al.
        Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases.
        Arch Surg. 2008; 143 ([discussion 982]): 978-982
        • Schnitzbauer A.A.
        • Lang S.A.
        • Goessmann H.
        • et al.
        Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings.
        Ann Surg. 2012; 255: 405-414
        • Olthof P.B.
        • Schnitzbauer A.A.
        • Schadde E.
        The HPB controversy of the decade: 2007-2017 - Ten years of ALPPS.
        Eur J Surg Oncol. 2018; 44: 1624-1627
        • Petrowsky H.
        • Linecker M.
        • Raptis D.A.
        • et al.
        First long-term oncologic results of the ALPPS procedure in a large cohort of patients with colorectal liver metastases.
        Ann Surg. 2020; 272: 793-800
        • Hasselgren K.
        • Rosok B.I.
        • Larsen P.N.
        • et al.
        ALPPS improves survival compared with TSH in patients affected of CRLM: survival analysis from the randomized controlled trial LIGRO.
        Ann Surg. 2021 Mar 1; 273: 442-448
        • Di Martino M.
        • Rompianesi G.
        • Mora-Guzman I.
        • et al.
        Systematic review and meta-analysis of local ablative therapies for resectable colorectal liver metastases.
        Eur J Surg Oncol. 2020 May; 46: 772-781
        • Gholami S.
        • Kemeny N.E.
        • Boucher T.M.
        • et al.
        Adjuvant hepatic artery infusion chemotherapy is associated with improved survival regardless of KRAS mutation status in patients with resected colorectal liver metastases: a retrospective analysis of 674 patients.
        Ann Surg. 2020; 272: 352-356
        • Okumura T.
        • Boku N.
        • Hishida T.
        • et al.
        Surgical outcome and prognostic stratification for pulmonary metastasis from colorectal cancer.
        Ann Thorac Surg. 2017; 104: 979-987
        • Handy J.R.
        • Bremner R.M.
        • Crocenzi T.S.
        • et al.
        Expert consensus document on pulmonary metastasectomy.
        Ann Thorac Surg. 2019; 107: 631-649
        • Treasure T.
        • Fallowfield L.
        • Lees B.
        Pulmonary metastasectomy in colorectal cancer: the PulMiCC trial.
        J Thorac Oncol. 2010; 5: S203-S206