The 2020 WHO Classification of Soft Tissue and Bone Tumors has incorporated a number
of changes to reflect recent advances made in the histopathologic and molecular diagnostic
workup of soft tissue tumors.
Keywords
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References
- WHO classification of tumours: soft tissue and bone tumours. 3. IARC Press, Lyon2020 (World Health Organization) 5th ed.
- WHO classification of tumours of soft tissue and bone.IARC Press, Lyon2013
- The 2020 WHO classification: what's new in soft tissue tumor pathology?.Am J Surg Pathol. 2021; 45: e1-e23
- Atypical spindle cell lipomatous tumor: clinicopathologic characterization of 232 cases demonstrating a morphologic spectrum.Am J Surg Pathol. 2017; 41: 234-244
- Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma.Virchows Arch. 2014; 465: 97-108
- Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases.Mod Pathol. 2010; 23: 729-736
- Atypical spindle cell/pleomorphic lipomatous tumor: a clinicopathologic, immunohistochemical, and molecular study of 20 cases.Pathol Int. 2018; 68: 550-556
- Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age.Am J Surg Pathol. 2009; 33: 645-658
- Adipose and myxoid tumors of childhood and adolescence.Pediatr Dev Pathol. 2012; 15: 239-254
- Liposarcomas of the mediastinum and thorax: a clinicopathologic and molecular cytogenetic study of 24 cases, emphasizing unusual and diverse histologic features.Am J Surg Pathol. 2012; 36: 1395-1403
- Array-based comparative genomic hybridization analysis of a pleomorphic myxoid liposarcoma.J Clin Pathol. 2014; 67: 834-835
- Comprehensive genetic analysis of a paediatric pleomorphic myxoid liposarcoma reveals near-haploidization and loss of the RB1 gene.Histopathology. 2016; 69: 141-147
- Myxoid pleomorphic liposarcoma-a clinicopathologic, immunohistochemical, molecular genetic and epigenetic study of 12 cases, suggesting a possible relationship with conventional pleomorphic liposarcoma.Mod Pathol. 2021; 34: 2043-2049
- Novel EWSR1-SMAD3 gene fusions in a group of acral fibroblastic spindle cell neoplasms.Am J Surg Pathol. 2018; 42: 522-528
- EWSR1-SMAD3-rearranged fibroblastic tumor: an emerging entity in an increasingly more complex group of fibroblastic/myofibroblastic neoplasms.Am J Surg Pathol. 2018; 42: 1325-1333
- EWSR1-SMAD3 rearranged fibroblastic tumor: case series and review.J Cutan Pathol. 2021; 48: 255-262
- EWSR1-SMAD3-positive fibroblastic tumor.Int J Surg Pathol. 2021; 29: 179-181
- Angiofibroma of soft tissue: clinicopathologic characterization of a distinctive benign fibrovascular neoplasm in a series of 37 cases.Am J Surg Pathol. 2012; 36: 500-508
- Histological spectrum of angiofibroma of soft tissue: histological and genetic analysis of 13 cases.Histopathology. 2016; 69: 459-469
- Soft tissue angiofibroma: clinicopathologic, immunohistochemical and molecular analysis of 14 cases.Genes Chromosomes Cancer. 2017; 56: 750-757
- Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.Genes Chromosomes Cancer. 2012; 51: 510-520
- Superficial CD34-positive fibroblastic tumor: report of 18 cases of a distinctive low-grade mesenchymal neoplasm of intermediate (borderline) malignancy.Mod Pathol. 2014; 27: 294-302
- Superficial CD34-positive fibroblastic tumour: a clinicopathological and immunohistochemical study of an additional series.Histopathology. 2017; 70: 394-401
- PRDM10-rearranged Soft tissue tumor: a clinicopathologic study of 9 cases.Am J Surg Pathol. 2019; 43: 504-513
- Inflammatory leiomyosarcoma: a morphological subgroup within the heterogeneous family of so-called inflammatory malignant fibrous histiocytoma.Histopathology. 1995; 27: 525-532
- So-called "inflammatory leiomyosarcoma'': a series of 3 cases providing additional insights into a rare entity.Int J Surg Pathol. 2005; 13: 185-195
- Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature.Mod Pathol. 2018; 31: 93-100
- Retained heterodisomy is associated with high gene expression in hyperhaploid inflammatory leiomyosarcoma.Neoplasia. 2012; 14: 807-812
- Inflammatory leiomyosarcoma shows frequent co-expression of smooth and skeletal muscle markers supporting a primitive myogenic phenotype: a report of 9 cases with a proposal for reclassification as low-grade inflammatory myogenic tumor.Virchows Arch. 2020; 477: 219-230
- Anastomosing hemangiomas: locations of occurrence, imaging features, and diagnosis with percutaneous biopsy.Abdom Radiol (NY). 2016; 41: 1325-1332
- Primary vascular tumors and tumor-like lesions of the kidney: a clinicopathologic analysis of 25 cases.Am J Surg Pathol. 2010; 34: 942-949
- Anastomosing hemangioma of the genitourinary tract: a lesion mimicking angiosarcoma.Am J Surg Pathol. 2009; 33: 1364-1369
- Pediatric anastomosing hemangioma: case report and review of renal vascular tumors in children.Pediatr Dev Pathol. 2019; 22: 269-275
- Frequent GNAQ and GNA14 mutations in hepatic small vessel neoplasm.Am J Surg Pathol. 2018; 42: 1201-1207
- Recurrent GNAQ mutations in anastomosing hemangiomas.Mod Pathol. 2017; 30: 722-727
- Recurrent GNA14 mutations in anastomosing haemangiomas.Histopathology. 2018; 73: 354-357
- A novel group of spindle cell tumors defined by S100 and CD34 co-expression shows recurrent fusions involving RAF1, BRAF, and NTRK1/2 genes.Genes Chromosomes Cancer. 2018; 57: 611-621
- Soft tissue tumors characterized by a wide spectrum of kinase fusions share a lipofibromatosis-like neural tumor pattern.Genes Chromosomes Cancer. 2020; 59: 575-583
- TRK inhibitors in TRK fusion-positive cancers.Ann Oncol. 2019; 30: viii23-viii30
- Recurrent NTRK1 Gene Fusions Define a Novel Subset of Locally Aggressive Lipofibromatosis-like Neural Tumors.Am J Surg Pathol. 2016; 40: 1407-1416
- Expanding the Spectrum of Pediatric NTRK-rearranged Mesenchymal Tumors.Am J Surg Pathol. 2019; 43: 435-445
- Evaluation of pan-TRK immunohistochemistry in infantile fibrosarcoma, lipofibromatosis-like neural tumour and histological mimics.Histopathology. 2018; 73: 634-644
- EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review.Hum Pathol. 2019; 90: 45-53
- EWSR1-NFATC2 and FUS-NFATC2 Gene Fusion-Associated Mesenchymal Tumors: Clinicopathologic Correlation and Literature Review.Sarcoma. 2019; 2019: 9386390
- NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker.Mod Pathol. 2020; 33: 1930-1944
- Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: a sarcoma with polyphenotypic differentiation.Am J Surg Pathol. 2019; 43: 220-228
- Clinical, pathological, and genomic features of EWSR1-PATZ1 fusion sarcoma.Mod Pathol. 2019; 32: 1593-1604
- EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor.Am J Surg Pathol. 2019; 43: 1112-1122
- Sarcomas With CIC-rearrangements are a distinct pathologic entity with aggressive outcome: a clinicopathologic and molecular study of 115 cases.Am J Surg Pathol. 2017; 41: 941-949
- Distinct transcriptional signature and immunoprofile of CIC-DUX4 fusion-positive round cell tumors compared to EWSR1-rearranged Ewing sarcomas: further evidence toward distinct pathologic entities.Genes Chromosomes Cancer. 2014; 53: 622-633
- Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics.Mod Pathol. 2016; 29: 1324-1334
- A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.Am J Surg Pathol. 2014; 38: 1571-1576
- Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion.Am J Surg Pathol. 2014; 38: 1724-1725
- A new subtype of bone sarcoma defined by BCOR-CCNB3 gene fusion.Nat Genet. 2012; 44: 461-466
- BCOR-CCNB3 Fusion Positive Sarcomas: A Clinicopathologic and Molecular Analysis of 36 Cases With Comparison to Morphologic Spectrum and Clinical Behavior of Other Round Cell Sarcomas.Am J Surg Pathol. 2018; 42: 604-615
- Novel BCOR-MAML3 and ZC3H7B-BCOR Gene Fusions in Undifferentiated Small Blue Round Cell Sarcomas.Am J Surg Pathol. 2016; 40: 433-442
- BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.Am J Surg Pathol. 2016; 40: 1670-1678
- Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Societe Francaise des Cancers de L'Enfant.Pediatr Blood Cancer. 2014; 61: 2191-2198
- Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients.J Clin Oncol. 2009; 27: 24-30
- Liposarcoma: a study of 55 cases with a reassessment of its classification.Am J Surg Pathol. 1979; 3: 507-523
- Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation.Mod Pathol. 1997; 10: 113-120
- Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria.Am J Surg Pathol. 2010; 34: 1122-1131
- Myogenic differentiation and histologic grading are major prognostic determinants in retroperitoneal liposarcoma.Am J Surg Pathol. 2015; 39: 383-393
- Nuclear expression of DDIT3 distinguishes high-grade myxoid liposarcoma from other round cell sarcomas.Mod Pathol. 2021; 34: 1367-1372
- Myxofibrosarcoma. Clinicopathologic analysis of 75 cases with emphasis on the low-grade variant.Am J Surg Pathol. 1996; 20: 391-405
- Biology and Management of Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma, and Malignant Peripheral Nerve Sheath Tumors: State of the Art and Perspectives.J Clin Oncol. 2018; 36: 160-167
- Clinicopathologic re-evaluation of 100 malignant fibrous histiocytomas: prognostic relevance of subclassification.J Clin Oncol. 2001; 19: 3045-3050
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Published online: May 31, 2022
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